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《医学前沿(英文)》 2017年 第11卷 第1期 页码 137-146 doi: 10.1007/s11684-016-0486-3
This study aims to elucidate the underlying molecular mechanisms of artemisinin accumulation induced by cadmium (Cd). The effects of different Cd concentrations (0, 20, 60, and 120 μmol/L) on the biosynthesis of Artemisia annua L. were examined. Intermediate and end products were quantified by HPLC-ESI-MS/MS analysis. The expression of key biosynthesis enzymes was also determined by qRT-PCR. The results showed that the application of treatment with 60 and 120 μmol/L Cd for 3 days significantly improved the biosynthesis of artemisinic acid, arteannuin B, and artemisinin. The concentrations of artemisinic acid, arteannuin B, and artemisinin in the 120 μmol/L Cd-treated group were 2.26, 102.08, and 33.63 times higher than those in the control group, respectively. The concentrations of arteannuin B and artemisinin in 60 μmol/L Cd-treated leaves were 61.10 and 26.40 times higher than those in the control group, respectively. The relative expression levels of HMGR, FPS, ADS, CYP71AV1, DBR2, ALDH1, and DXR were up-regulated in the 120 μmol/L Cd-treated group because of increased contents of artemisinic metabolites after 3 days of treatment. Hence, appropriate doses of Cd can increase the concentrations of artemisinic metabolites at a certain time point by up-regulating the relative expression levels of key enzyme genes involved in artemisinin biosynthesis.
关键词: Cd secondary metabolites gene expressions Artemisia annua L.
In memory of Perry L. McCarty, seminal founder of Environmental Biotechnology
《环境科学与工程前沿(英文)》 2023年 第17卷 第10期 doi: 10.1007/s11783-023-1730-0
Comments on the special issue on forestry of
John L. INNES
《农业科学与工程前沿(英文)》 2017年 第4卷 第4期 页码 502-503 doi: 10.15302/J-FASE-2017189
Shear design of high strength concrete prestressed girders
Emad L. LABIB,Hemant B. DHONDE,Thomas T. C. HSU,Y. L. MO
《结构与土木工程前沿(英文)》 2014年 第8卷 第4期 页码 373-387 doi: 10.1007/s11709-014-0087-7
关键词: shear design high strength concrete prestressed girders full-scale tests
Purification of artemisinin from quercetin by anti-solvent crystallization
Chandrakant R. MALWADE, Haiyan QU, Ben-Guang RONG, Lars P. CHRISTENSEN
《化学科学与工程前沿(英文)》 2013年 第7卷 第1期 页码 72-78 doi: 10.1007/s11705-013-1305-x
关键词:
anti-solvent crystallization
artemisinin
quercetin
solubility
Deeply missing my career idol and role model ― Professor Perry L. McCarty
《环境科学与工程前沿(英文)》 2023年 第17卷 第9期 doi: 10.1007/s11783-023-1717-x
Urban watershed management under rapid urbanization
Pengfei DU, Haifeng JIA, Shaw L. YU
《环境科学与工程前沿(英文)》 2012年 第6卷 第5期 页码 595-595 doi: 10.1007/s11783-012-0452-5
Raymond L. Sterling
《工程(英文)》 2017年 第3卷 第6期 页码 780-781 doi: 10.1016/j.eng.2017.12.006
A Standard for the Commissioning Process
William L. Gillis,Elizabeth A. Cudney
《工程管理前沿(英文)》 2015年 第2卷 第1期 页码 39-51 doi: 10.15302/J-FEM-2015006
关键词: construction engineering management quality commissioning
The Decarbonization of Construction—How Can Alkali-Activated Materials Contribute?
John L. Provis,Susan A. Bernal,Zuhua Zhang,
《工程(英文)》 doi: 10.1016/j.eng.2023.09.014
Quality Function Deployment Implementation in Construction: A Systematic Literature Review
Cudney,William L. Gillis
《工程管理前沿(英文)》 2016年 第3卷 第3期 页码 224-230 doi: 10.15302/J-FEM-2016036
关键词: construction engineering management quality function deployment systematic review
Effects of iron oxide nanoparticles on phenotype and metabolite changes in hemp clones ( L.)
《环境科学与工程前沿(英文)》 2022年 第16卷 第10期 doi: 10.1007/s11783-022-1569-9
● Fe3O4 NPs increased the biomass and chlorophyll content of hemp clones.
关键词: Fe3O4 nanoparticle Hemp Growth enhancement THC Metabolite
PAVLOVA, L. L. ZAVALOVA, I. P. BASKOVA
《化学科学与工程前沿(英文)》 2012年 第6卷 第2期 页码 203-209 doi: 10.1007/s11705-012-1277-2
关键词: recombinant destabilase-lysozyme (rec.Dest-Lys) antimicrobial activity antifungal activity medicinal leech heated-up derivative of rec.Dest-Lys (T-rec.Dest-Lys)
Lim, Peck L. Kiew, Steven Lim, Siti S. Rosli, Chung Y. Wong, Pau L. Show, Keat T. Lee
《化学科学与工程前沿(英文)》 2021年 第15卷 第5期 页码 1257-1268 doi: 10.1007/s11705-020-2015-9
Reduced texaphyrin: A ratiometric optical sensor for heavy metals in aqueous solution
Root, Gregory Thiabaud, Jonathan L. Sessler
《化学科学与工程前沿(英文)》 2020年 第14卷 第1期 页码 19-27 doi: 10.1007/s11705-019-1888-y
关键词: texaphyrin fluorescent sensor ion-sensing indium mercury
标题 作者 时间 类型 操作
Effects of different doses of cadmium on secondary metabolites and gene expression in Artemisia annuaL.
null
期刊论文
Shear design of high strength concrete prestressed girders
Emad L. LABIB,Hemant B. DHONDE,Thomas T. C. HSU,Y. L. MO
期刊论文
Purification of artemisinin from quercetin by anti-solvent crystallization
Chandrakant R. MALWADE, Haiyan QU, Ben-Guang RONG, Lars P. CHRISTENSEN
期刊论文
The Decarbonization of Construction—How Can Alkali-Activated Materials Contribute?
John L. Provis,Susan A. Bernal,Zuhua Zhang,
期刊论文
Quality Function Deployment Implementation in Construction: A Systematic Literature Review
Cudney,William L. Gillis
期刊论文
Antifungal and antibacterial functions of medicinal leech recombinant destabilase-lysozyme and its heated-up derivative
PAVLOVA, L. L. ZAVALOVA, I. P. BASKOVA
期刊论文
Simultaneous harvesting and cell disruption of microalgae using ozone bubbles: optimization and characterization study for biodiesel production
Lim, Peck L. Kiew, Steven Lim, Siti S. Rosli, Chung Y. Wong, Pau L. Show, Keat T. Lee
期刊论文